Lymphocytes Analysis Method Based on CFSE Labeling of Development of a Novel Limiting Dilution than Matching B Lymphoblastoid Cells: Pre-CTL and Induce Less Clonal Expansion + a Lower Frequency of Alloreactive CD8 Human Vascular Endothelial Cells Stimulate
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Human vascular endothelial cells stimulate memory but not naive CD8+ T cells to differentiate into CTL retaining an early activation phenotype.
Endothelial cell (EC)-selective alloreactive CTL may mediate alloimmune vascular injury. In the present study, EC-selective CTL were generated in cocultures of purified human CD8+ T cells with allogeneic EC and were compared with conventional CTL against corresponding B lymphoblastoid cells (BLC). EC caused activation and expansion of memory but not naive CD8+ T cells, which differentiated into...
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تاریخ انتشار 2001